Casper Is In Critical Condition
I am posting updates on his situation on this message board. We appreciate all the love and support from all of you.
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I was diagnosed with Evans Syndrome in 2006. It is a combination of IMHA/AIHA (Immune Mediated Hemolytic Anemia/Auto-Immune Hemolytic Anemia) and IMT/ITP (Immune Mediated Thrombocytopenia/Immune Thrombocytopenic Purpura). I was hospitalized for over a week and received numerous blood transfusions and a cocktail of immunosuppressants to save my life. I was weaned off the medications due to complications such as Cushings Disease but after a few months off the drugs, I relapsed again so I am currently back on medication. I continue to fight this disease everyday.
There is no cure for this disease so please help support the fight for a cure. Meisha's Hope Fund and Morris Animal Foundation has teamed up to find a cure for IMHA with Autoimmune/Immune-Mediated Hemolytic Anemia Fund #338.
Immune-Mediated Hemolytic Anemia is a serious blood disorder and scientists estimate over 50% of dogs diagnosed with it will die from the condition. Affected dogs show signs of weakness, lethargy, exercise intolerance and anorexia. This deadly blood disorder occurs when something triggers the dog's body to attack its own red blood cells. Despite aggressive immunosuppressive therapy, this disease has a very high mortality rate. Many dogs die shortly after diagnosis, so an effective early treatment is critical.
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28 Comments:
My humans and I are so very sorry to read this. This is very sad news, and we are sure that you, his family, are very sad and worried right now. We will pray for Casper and for his family.
Love,
Indy and his humans
This is terrible. I am very sorry to hear this. Love and prayers go along way, my parents as well as myself will be praying for a full recovery, so that Casper can return home to be with his loving family.
For Casper and his family, here is some good information and a hopeful story about a collie with Evans Syndrome:
http://beardie.net/bcca/health/evans_syndrome.shtml
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Oh! I'm so sorry to hear that! My humans and I will say prayers for Casper as well.
Hope Casper has a quick and full recovery.
Raisa
This must be terribly difficult for you. We sure hope Casper recovers and gets home with you soon.
Sending purayers and bunny nose kisses your way!
Lots of nose bumps from me, Mrs. Sniffles, and my bunny people. Bunny Daddy tells me that he used to have an american eskie and really hopes Casper pulls through.
we are so very sorry for your difficult time. we hopeing Casper can return home to be with his family very soon.
Hang in there Casper! Hope you get well soon.
I do hope that Casper is better soon. He is in our prayers. Keep us posted on his condition!
We hope that Casper gets better soon! He is a good looking woofie (we like dogs virtually rather than in reality). Purrayers, headbutts and sandpaper kisses to Casper and his Mom!!
The Monsters and their Mom
God Bless Casper, I hope you get well soon, little one. Take care.
Hi Casper.. I'm praying for you!
We shall think and pray for you and your loved one.
Chin up and be strong for Casper!
We saying our purrayers for Casper & his family.
So sorry to hear about Casper. Our families prayers are with you and yours. Give Casper a kitty kiss and a head bonk for us.
casper,
purrayers and fluffie love to you and your beans.
and kitty kisses to make you well again
charlie and pandora
ps we have updated Secret Paw with your mama's latest Eskie bulletin board posting - hope you don't mind, but the more love the better, eh? :-)
Mama has been doing some research, probably as you have, and has found this drug which is being used on lymphoma.
Rituximab
How does it work?
Rituximab is a medicine that is known as a monoclonal antibody. Monoclonal antibodies are proteins which specifically recognise and bind to another unique protein called an antigen. Cancers form when some cells within the body multiply uncontrollably and abnormally. There are two types of cancer. Solid cancers where a lump forms e.g. the bone, muscle, brain cells etc. divide and multiply abnormally. The second type are leukaemias and lymphomas where the blood cells divide and multiply abnormally. Rituximab binds to an antigen called CD20 which is found on a type of white blood cell called a B cell lymphocyte. B cell lymphocytes form part of the immune cells responsible for regulating and triggering immune responses and therefore provide defence against infection and foreign cells. In the disease lymphoma, abnormal B cell lymphocytes are produced. Rituximab by binding to these B lymphocytes destroys them and this offers a way of treating the lymphoma in cases where other chemotherapy has not worked. Rituximab is administered by intravenous infusion only.
This is where she found the reference:
A patient with CIDP developed Evans’syndrome despite of different immunomodulatory treatments (corticosteroids, intravenous immunoglobulins (IVIg), plasma exchange, azathioprine and cyclophosphamid) 17 months after onset of symptoms. In persence of progressive disease (Rankin scale 4) a new therapeutic approach with the chimeric monoclonal anti-CD20 antibody rituximab, that destroys B-cells from the early pre-B stage through maturation up to plasmacytoid stage, was decided. Applying a clinical protocol (rituximab 375mg/m2 at days 1, 8, 15, 22) our patient normalized the platelet count already at the end of the fourth rituximab infusion. A total of five additional single courses over one year were performed. 17 months after completion of therapy signs and symptoms of CIDP have nearly disappeared (Rankin scale 1). Thus, rituximab may represent a successful therapy in otherwise refractory CIDP.
http://www.iscos.org.uk/abstracts2004/abstracts24.html
We don't know if this helps - we hope it does.......
charlie and pandora
We all send blessing and good wishes. Buster and Liberty are sending doggie prayers and if Casper wants it, I'll send Reiki. I hope he gets well soon!
Hang in there Casper! We're praying for you to get well soon, and sending lots of puppy kisses to you & your family.
Love,
Leader Dog Willow, and Stella
Please, get well soon! I keep coming here all the time looking for good news!
Saying prayers for you!
Raisa
Casper,
You will be fine soon, be strong !!
be strong !! be strong !!
be strong !! be strong !!
Get well soon Casper! I'm sure the humans will spoil you rotten the moment you get home, so you have that to look forward to.
Get well soon casper!
Sorry to hear that you got in trouble Caspy, but I am sure you will be ok soon...
With all the love from your Mom and friends you are going to be ok soon.
Take good care of yourself and check what caused the issue, so you don't run into it next time.
Sorry to hear about Casper, I was hoping your baby would make it where as my Mindi didn't. By looking at all the well wishers i'm sure alot of prayers are being said. I do pray for Casper that he can pull through this Sue,
suziepugs@aol.com
I have stopped in to check on updates on Little Casper. His picture looks great. It really looks like the vets have him under control. I pray for that and that he will do just fine
Sue Mindi Mom
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